Endotherm Dokumente
2020
Publikationen
Putkaradze N, König L, Kattner L, Hutter MC, Bernhardt R: Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1. Biochem Biophys Res Commun 2020; in press. doi.org/10.1016/j.bbrc.2020.01.091
Kattner L: Recent developments towards the synthesis of vitamin D metabolites. Anticancer Res 2020;40:519-525. doi:10.21873/anticanres.13980
Patente
EP 2 933 246 B1
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES
(Europäisches Patent)
DE 10 2013 107 885 A1
„Biokatalysator zur Produktion von 25-OH-Vitamin D3 und anderen hydroxylierten Vitamin D3 Derivaten mittels rekombinanter Bacillus megaterium Stämme"
(Deutsche Patentanmeldung)
2019
Publikationen
Mäder P: Boron in Medicinal Chemistry: Powerful, but Neglected. Chimia 2019;73:637–638.
Sonstiges
2018
Publikationen
Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine 2018;10:eaan0724. DOI: 10.1126/scitranslmed.aan0724
Patente
US 9,994,508 B2
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (US-Patent)
Sonstiges
2017
Publikationen
Mohamed, B. A., Kattner, L., Guan, K., Lehnart, S. E., Luther, S., Sossalla,S., et al.: The relevant role of SR Ca leak in the development of heart failure. European Journal of Heart Failure 2017; 19(Suppl_1): 343-343.
Kattner L, Bernardi D: An Efficient Synthesis of 1alpha,25-Dihydroxyvitamin D3 LC-Biotin. J Steroid Biochem Mol Biol. 2017;173:89-92.
Kattner L, Volmer DA: Synthesis of Low Abundant Vitamin D Metabolites and Assaying Their Distribution in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) as a New Tool for Diagnosis and Risk Prediction of Vitamin D related Diseases In: A Critical Evaluation of Vitamin D - Basic Overview, Sivakumar Gowder (editor), Intech publishers, Rijeka. 2017;103-127. ISBN 978-953-51-3084-0.
Auszeichnungen
Sonstiges
Flyer: Your partner for vitamin D synthesis
2016
Publikationen
Kattner L, Rauch E: Optimization of Chemical Syntheses of Vitamin D C3-Epimers. Anticancer Res 36(3):1417-1422, 2016.
Auszeichnungen
Sonstiges
2015
Publikationen
Kattner L, Bernardi D, Rauch E: Development of Efficient Chemical Syntheses of Vitamin D Degradation Products. Anticancer Res 35(2):1205-1210, 2015.
Poster, Symposium “Biological Effects of Light”, Homburg: Optimization of Chemical Syntheses of Vitamin D C3-Epimers.
Patentanmeldungen
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (Europäische Patentanmeldung)
VERSATILE AND FUNCTIONALIZED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES (US-Patentanmeldung)
2014
Publikationen
Azimi Hashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF: Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications (5):1-12, 2014.
Patentanmeldung
Vortrag
2013
Publikationen
Sotoud H, Gribbon P, Ellinger B, Reinshagen J, Boknik P, Kattner L, El-Armouche A, Eschenhagen Th: Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches. J Biomol Screen 18(8):899-909, 2013.
Bourgonje VJ, Vos MA, Ozdemir S, Doisne N, Acsai K, Varro A, Sztojkov-Ivanov A, Zupko I, Rauch E, Kattner L, Bito V, Houtman M, van der Nagel R, Beekman JD, van Veen TA, Sipido K, Antoons G: Combined Na+/Ca2+ Exchanger and L-Type CalciumChannel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function. Circulation: Arrhythm Electrophysiol. 6:371-379, 2013.
Scholz T, Heyl CL, Bernardi D, Zimmermann S, Kattner L, Klein CD: Chemical, Biochemical and Microbiological Properties of a Brominated Nitrovinylfuran with Broad-Spectrum Antibacterial Activity. Bioorg Med Chem, 21:795-804, 2013.
Patent
Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de ES-2396524_B2
2012
Publikationen
2011
Publikationen
Poster, Workshop on Vitamin D, Homburg: Development of commercially applicable syntheses of Vitamin D derivatives
Vortrag
2010
Publikationen
2009
Publikationen
Steuer Ch, Heinonen KH, Kattner L, Klein CD: Optimization of assay Conditions for Dengue Virus protease. Effect of various Polyols and Nonionic Detergents. J Biomol Screen. 14(9):1102-1108, 2009.
Poster “Frontiers in Medicinal Chemistry”, Heidelberg: Identification of Lead Compounds for Dengue NS3 Protease Inhibitors.
Sotoud H, Kattner L, Eschenhagen Th, El-Armouche A
Colorimetric protein phosphatase inhibition assay for specific detection of phosphatase-inhibitor-1 inhibitory compounds Archiv für Experimentelle Pathologie und Pharmakologie 2009.
Auszeichnungen
2008
Publikationen
Holzer M, Ziegler S, Albrecht B, Kronenberger B, Kaul A, Bartenschlager R, Kattner L, Klein CD, Hartmann RW: Identification of Terfenadine as an Inhibitor of Human CD81-receptor HCV-E2 Interaction: Synthesis and Structure Optimization. Molecules.13:1081-1110, 2008.
Auszeichnungen
2007
Publikationen
Outsourcing of medicinal chemistry in the drug discovery process faces CRO´s and pharmaceutical companies with challenges. PharmChem. 2007, July/August, 6-7.
Auszeichnungen
